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A rejoint le : 14 mai 2022

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 . . of the domain www.allkeys.comA new platelet specific binding site for the antitumour drug thioguanine. Thioguanine (TG) is a nucleoside antimetabolite which inhibits both purine and pyrimidine synthesis. This drug is widely used in the treatment of acute myelogenous and lymphoblastic leukaemia. The binding of TG to red blood cells, platelets and haemoglobin has been described previously. In this report a new platelet specific binding site for TG is described. It was found to be saturable, reversible and specific, and the binding parameters were calculated. Our findings suggest that the biological effect of TG in platelets may be due to its action at this binding site.The Mets are looking for a 3rd baseman. In a recent interview with Mike Francesa on WFAN, Ruben Amaro Jr. was asked if the team had looked at Eric Campbell, and his reply was “I think that maybe we did”. Amaro said that they did look at Campbell last year, and he was not in their plans this year. Campbell was mentioned as the Mets “favorite” for a backup 3rd base role after the Mets acquired Lucas Duda, which makes sense because Duda is a better fit in the 3rd spot than Campbell. However, it is not clear how Amaro would judge him as a backup option for the team.Development of antibody microarrays based on microstructured hydrogels and their application to measure the antibody-antigen interaction. We describe a method that uses microstructured hydrogels to obtain antibody microarrays. Microstructured hydrogels are prepared with a porous structure which allows antibody molecules to be immobilized and their biological activity preserved. Several molecules, including antibody, antigen and their mixtures, are bound to these hydrogels for the investigation of the antibody-antigen interaction. When binding reactions take place, the amount of free antigen adsorbed to the microstructured hydrogel is measured by the enzyme-linked immunosorbent assay (ELISA). Using this method, we demonstrate that mixtures of antigens prepared with different ratios of 2 antigens bind selectively to their specific antibodies. In addition, we show that ELISA is a useful method for the detection of antigen-antibody interactions because the binding signal is not affected by other substances even in the

 

 

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